堛妛惗棟妛尋媶強偼搶嫗戝妛昦堾偲嫟摨偱擠怭崅寣埑徢岓孮偺尨場暔幙sFlt-1偑憹壛偡傞尨場偺堦晹傪夝柧偟丄崙嵺妛弍帍偵榑暥敪昞偡傞偲偲傕偵丄侾俀寧俇擔偵導挕偱婰幰敪昞傪峴偄傑偟偨丅

榑暥丗
Title: HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts
Tadashi Sasagawa, Takeshi Nagamatsu, Kazuki Morita, Nobuko Mimura, Takayuki Iriyama, Tomoyuki Fujii, and Masabumi Shibuya
Scientific Reports, Nov. 26, 2018

擠怭崅寣埑徢岓孮偺尨場暔幙sFlt-1偑憹壛偡傞尨場偺堦晹傪夝柧

1, 擠怭崅寣埑徢岓孮乮埲慜偺屇傃曽偱偼擠怭拞撆徢乯偼丄擠晈偺栺俆亾偑敪徢偡傞廳梫側昦婥偱丄廳徢偺応崌偼曣懱傗戀帣偺柦偵傕塭嬁傪梌偊傞丅
嬤擭丄戀斦偺塰梴憌嵶朎偐傜sFlt-1僞儞僷僋幙偑堎忢偵嶻惗偝傟丄曣懱寣棳拞偵傕棳傟偰丄崅寣埑傗僞儞僷僋擜傪堷偒婲偙偡偙偲偑師戞偵柧傜偐偵側偭偰偒偨丅

2, sFlt-1偺嶻惗偑憹戝偡傞桿場偲偟偰偼丄戀斦偺巁慺寚朢乮掅巁慺乯丄妶惈巁慺偺桿摫丄墛徢丄側偳偑曬崘偝傟偰偄傞偑丄徻嵶側暘巕婡峔偵偮偄偰偼晄柧偺傑傑偱偁偭偨丅

3, 忋晲戝妛丒堛妛惗棟妛尋媶強偺嶚愳尋媶堳丄郌扟尋媶強挿傜偼丄搶嫗戝妛昦堾乮彈惈恌椕壢丒嶻壢丗摗堜抦峴嫵庼偺僌儖乕僾乯偲嫟摨偱尋媶傪峴偄丄戀斦塰梴憌嵶朎偑掅巁慺娐嫬偵偍偄偰偼揮幨場巕HIF2a傪棙梡偟偰sFlt-1堚揱巕敪尰傪槾恑偝偣丄sFlt-1戝検嶻惗傪摫偔偙偲傪柧傜偐偵偟偨丅榑暥偼丄杮擭11寧26擔偵丄崙嵺妛弍帍 Scientific Reports 偵敪昞乮昅摢挊幰丗T. Sasagawa, 愑擟挊幰丗M. Shibuya乯丅

4, 揮幨場巕HIF2a偼僸僩恡憻偑傫傗擼庮釃偺埆惈壔偵娭梌偡傞偙偲偑嵟嬤柧傜偐偵偝傟偨偙偲偐傜丄惂偑傫嵻偲偟偰HIF2a慾奞栻偺椪彴帋尡偑峴傢傟偰偄傞抜奒偱偁傞丅尰嵼丄擠怭崅寣埑徢岓孮偵懳偡傞桳岠側帯椕栻偼傑偩奐敪偝傟偰偄側偄偑丄崱夞偺嫟摨尋媶偺惉壥傪傕偲偵丄彨棃丄擠怭崅寣埑徢岓孮偺帯椕栻偺傂偲偮偲偟偰暃嶌梡偺側偄HIF2a慾奞栻偑峫偊傜傟傞丅偦偺栻嵻奐敪偑婜懸偝傟傞丅

拲丗
flt-1堚揱巕丗sFlt-1傪嶻惗偡傞堚揱巕偱丄郌扟強挿偑搶戝堛壢妛尋媶強嫵庼偺帪戙偵丄僸僩僎僲儉偐傜敪尒偟偰悽奅偵曬崘偟偨傕偺丅寣娗怴惗傗墛徢丄偑傫揮堏側偳偵娭梌偡傞丅