愢柧暥丗
彫帣媫惈崪悜惈敀寣昦(AML)偺挿婜惗懚棪偼偄傑偩60?70%掱搙偱偁傝丄帯椕惉愌偺岦忋偑朷傑傟傞彫帣娻偱偁傞丅椦媞堳嫵庼偲孮攏戝妛偼嫟摨偱AML偺椪彴専懱傪梡偄偨夝愅傪峴偄丄偑傫梷惂堚揱巕偲偟偰抦傜傟傞TP53媦傃RB1偵惗偠偨堚揱巕堎忢傪摨掕偟丄偦偺暘巕惗暔妛揑媦傃椪彴揑堄媊傪柧傜偐偵偟偰榑暥敪昞偟偨丅
擔杮彫帣敀寣昦儕儞僷庮尋媶僌儖乕僾AML-05椪彴帋尡偵搊榐偝傟偨328徢椺傪懳徾偵僒儞僈乕僔乕働儞僗朄偲師悽戙僔乕働儞僒乕傪梡偄丄娻娭楢堚揱巕偺栐梾揑側夝愅傪峴偭偨丅TP53媦傃RB1堚揱巕堎忢偼偦傟偧傟2.1%丄1.8%偺徢椺偱専弌偝傟偨丅偄偢傟偐偺堚揱巕堎忢傪桳偡傞徢椺偺梊屻偼摑寁妛揑偵桳堄偵梊屻晄椙偱偁偭偨丅傑偨丄偙傟傜偺堚揱巕堎忢傪桳偡傞徢椺偱偼SLC2A5丄KCNAB2丄媦傃CD300F堚揱巕偑崅敪尰偟偰偍傝丄偙傟傜偺堚揱巕偑崅敪尰偟偰偄傞徢椺偼TP53偲RB1堚揱巕堎忢偺桳柍偵娭傢傜偢梊屻晄椙偱偁偭偨丅杮尋媶偱摼偨抦尒偑AML偺帯椕惉愌岦忋偵婑梌偡傞偙偲偑婜懸偝傟傞丅
Hara Y, Shiba N, Yoshida K, Yamato G, Kaburagi T, Shiraishi Y, Ohki K, Shiozawa Y, Kawamura M, Kawasaki H, Sotomatsu M, Takizawa T, Matsuo H, Shimada A, Kiyokawa N, Tomizawa D, Taga T, Ito E, Horibe K, Miyano S, Adachi S, Taki T, Ogawa S, Hayashi Y. TP53 and RB1 alterations characterize poor prognostic subgroups in pediatric acute myeloid leukemia. Genes Chromosomes Cancer. 2023 Jul;62(7):412-422. doi: 10.1002/gcc.23147. Epub 2023 Apr 27. PMID: 37102302.
恾1. TP53媦傃RB1堚揱巕堎忢偲懠偺堚揱巕堎忢偲偺娭楢
